Inductive signaling

Terinductive cell-cell signaling. Synonyms: inductive cell-cell signalling. This is often done by secretion of proteins by one cell which . Although one of the classic models for signaling involves diffusion, there is new evidence that inductive signals may in fact be actively transported within and between cells, and that cellular projections may be involved in long distance communication between cells.

Video created by Duke University for the course Medical Neuroscience.

This module represents another turning point in Medical Neuroscience.

Now that we have surveyed human neuroanatomy and our sensory and motor systems, we are ready to take a.

For example, in the developing chick and mammalian eye, the Paxprotein appears to be important in making the ectoderm competent to respond to the . Inductive signal and tissue responsiveness defining the tectum and the cerebellum. Sato T(1), Araki I, Nakamura H. Notch signaling also operates in control of lineage decisions and inductive signaling between nonequivalent cells. In these cases, the cells are initially distinct from each other either because they asymmetrically express regulators of the Notch pathway or because the ligand and receptor are differentially distributed in . Inductive Tissue Interactions, Cell Signaling , and the Control of Kidney Organogenesis.

Search for articles by this author. The responding cells, in turn, can become inductive and change the fate of their neighbors by producing new signals, thus generating sequential inductive events that increase cell-fate diversity in tissues. Identification and characterization of the signaling pathways involved in development has led to the surprising . The candidate signaling molecule is Fgfwhose mRNA is localized in the region where the cerebellum differentiates. Responding to this signal , the cerebellum differentiates in the metencephalon and the tectum differentiates in the mesencephalon. Based on the assumption that strong Fgfsignal induces the cerebellum . Transient activation of the highly conserved extracellular- signal -regulated kinase (ERK) establishes precise . Msxcontrols inductive signaling in mammalian tooth morphogenesis.

Chen Y(1) , Bei M, Woo I, Satokata I, Maas R. Members of the Msx homeobox family are . In undifferentiated endoderm cells, the FoxA and GATA transcription factors are among the first to engage silent genes, . All of these structures are in position to signal to the neuroectoderm, and therefore to convert it to epidermis. This epidermal fate is evidently avoided in the neural plate by the local activity of other inductive signaling molecules called noggin and chordin. Both of these molecules bind directly to the BMPs and thus prevent . Cold Spring Harb Symp Quant Biol. Pioneer factors, genetic competence, and inductive signaling : programming liver and pancreas progenitors from the endoderm. Zaret KS(1), Watts J, Xu J, Wandzioch E, Smale ST, Sekiya T. Extracellular matrix microarrays to study inductive signaling for endoderm specification.

The earliest stages of plant embryo development involve groups of cells acquiring the competence to respond to inductive signals. Later in development, inductive signaling also becomes important. For example, in flowering plants the distance between nodes along the stem elongates, and lateral buds form below the shoot . Inductive interactions between neighboring cells is the most common mode of tissue patterning.

As embryos develop, the new cells need to figure out what their role is in the organism.